The PROSPER study is a randomized, double-blind, placebo-controlled trial[3] that has successfully recruited the planned number of 220 participants with PSP in just 14 months, achieving this milestone on October 6th, two months ahead of schedule. A total of 44 centers across the European Union, the United Kingdom, and the United States are participating. The study design includes a six-week screening period, followed by 52 weeks’ treatment with either FNP-223 or placebo and a subsequent four-week follow-up period after the completion of treatment[3].

The study focuses on participants with early-stage progressive supranuclear palsy-Richardson syndrome (PSP-RS), a critical stage during which early intervention may have the greatest impact on slowing disease progression. Identifying the disease at this stage is a significant challenge due to its rapid progression and diagnostic complexity, making the achievement of this recruitment milestone ahead of schedule even more meaningful.

Prof. Dr. Med. Günter Höglinger, from the Ludwig-Maximilian University of Munich, and principal investigator and coordinator of the PROSPER study, stated: “I am deeply grateful to the patients, their caregivers, and the dedicated teams at our academic centers for their outstanding commitment, which has enabled us to reach this important milestone so swiftly. Together, we are making significant progress toward answering a critical scientific question: the role of OGA inhibition in PSP. Our shared efforts bring us closer to developing solutions that may truly improve the lives of patients.”

According to Kristophe Diaz, Chief Executive Officer of CurePSP, “Achieving full enrollment in a PSP clinical trial is no small feat, and Ferrer’s success with the PROSPER study is both a scientific and human milestone. Behind this progress are patients and families who choose to turn hope into action, and their participation accelerates the entire ecosystem toward meaningful therapies for PSP. For our community, each step like this brings us closer to lasting change.”

Oscar Pérez, Chief Scientific Officer at Ferrer, noted: “The early completion of recruitment marks a key step in Ferrer’s commitment to accelerating clinical research programs for complex and rare diseases such as PSP. In line with our purpose of using business to fight for social justice, we hope to deliver a potential solution that transforms the lives of people affected by this disease and those around them. We are deeply grateful to the patients, families, caregivers, investigators and patient associations for their trust and support, without which this milestone would not have been possible.”

Ferrer has also incorporated input from patients, caregivers, and healthcare professionals into the design of the PROSPER study, with the goal of tailoring clinical research to the real needs of participants, improving their experience, and ensuring more impactful clinical research.

Ferrer’s commitment to research

Ferrer is an international company based in Barcelona, strongly committed to the research and development of innovative therapies in areas of high unmet medical need, such as rare neurological diseases and pulmonary vascular and interstitial diseases. The company focuses on complex, global clinical developments, advancing projects across multiple stages of research.